Independent Structural Risk Assessment for Cryo-EM Programs

Built for decision workflows in structural biology and drug discovery.

Designed to integrate with existing structural biology workflows without disrupting internal processes.

Evaluates reconstructed cryo-EM maps for decision support.
Delivers a concise risk memo to support program-level Go/No-Go alignment prior to additional structural or experimental investment. i Decision-focused assessment of reconstructed cryo-EM maps, summarized in a concise risk memo to support program-level Go/No-Go decisions prior to further structural or experimental investment.

Start Confidential Review Request NDA / Security Summary

Operates as a risk assessment function with experience in large-scale structural data environments.

Standard NDA template available. Compatible with standard client procurement processes.

Scope

Accepted inputs: reconstructed maps (.mrc / .map)
Evaluation focus: map consistency, regional confidence, ligand pose support (if applicable) iMap-level review of density evidence for structural consistency and region-specific confidence. Where a ligand interpretation is provided, ligand pose support is assessed from density evidence only (not docking, pose generation, or simulation).
Exclusions: no raw data processing, no particle picking, no map reconstruction, no full structure delivery iScope excludes micrograph preprocessing, particle picking/extraction, 3D reconstruction, and atomic model building/delivery. This service is a decision-oriented map assessment based on reconstructed cryo-EM maps.

Deliverables (Decision-Ready)

Executive Risk Memo with explicit assumption & uncertainty framing iDecision-focused document summarizing structural evidence quality and uncertainty.
Quantitative structural consistency indicatorsiQuantitative measures describing density coherence and interpretability.
Region-level confidence assessmentiLocalized reliability estimates across spatial segments of the density map.
Decision-impact summary suitable for internal review decks
Applicable before downstream computational modeling (including FEP) or experimental commitment

Engagement Model

Engagement format: rapid triage, case review, or program support iFlexible scope based on a single decision point or broader program needs.
Procurement-ready: one-off or repeat engagements under NDA iCan be set up as a single assessment or repeated work under an existing NDA.
Decision timing: aligned to stage-gates and Go/No-Go checkpoints iDesigned to support internal decision points before further modeling or experiments.
Commercial model: project-based billing, case-specific scope iPricing is scoped per case based on complexity and turnaround.

Built for industry decision workflows and lean team operations.

Process & Timeline

Day 0

Data intake & Scope alignment (Go/No-Go criteria)

Day 1–3

Structured evaluation & density-evidence review

Day 4–5

Decision memo delivery (risk assessment + decision-ready summary)

Accelerated triage iDefined-scope urgent review intended for rapid red-flag screening, not a full decision memo.

48-hour red-flag review for defined-scope urgent cases

Confidentiality & Data Governance

Reconstructed maps only (no raw data required).
Encrypted transfer options available.iSecure data transmission using industry-standard cryptographic protocols.
Client data is segregated per engagement.iData isolation ensuring no cross-project access or commingling.
No cross-project reuse or incorporation into shared datasets.
No model training or data retention beyond the agreed scope.iDuration of stored client data prior to secure deletion.
Default deletion within 30 days unless otherwise agreed.
NDA available upon request.
Designed to minimize IP exposure and align with client confidentiality requirements.